Reliquary of the Blessed Blood is a relic that can be found in The Darkness 2. It is a container that was meant to hold The Angelus, and can be seen as a predecessor for the Prism of the Brothers.
The Reliquary of the Blessed Blood was the first attempt by the Brotherhood to create a vessel to contain the Angelus. However, it only managed to infuriate the Angelus into burning the Brotherhood members. The Reliquary is also said to contain Jesus Christ's foreskin. According to Johnny Powell, however, the foreskin in the container belongs to a man named "Miles from South Hammingtonshire".